主要从事空间辐射生物学研究，具体包括空间辐射生物学效应及其调控机制、空间辐射生物标志物的筛选及辐射生物计量、辐射生物物理模型、空间辐射健康风险评估与防护、空间生物信息学与数据挖掘等研究工作。主持1项国家重大科技专项载人航天工程空间站科学与应用项目、2项空间站科学实验项目课题、1项国家重点研发计划子课题、2项国家自然科学基金项目、多项省部级项目等。在国内外期刊，如Protein & Cell、NPJ Microgravity、Astrobiology、Ecotox Environ Safe、Radiat Res、Life Sci Space Res、Mutat Res/Fund Mol M等，发表学术论文47篇；制定国家标准1项（中英文版本）；申请/授权发明专利7项；获得2项辽宁省自然科学学术成果奖、2项国际空间研究委员会青年科学家杰出论文奖、7项学会优秀论文奖，连续2年入选《中国空间站科学研究与应用进展报告》代表性成果，相关成果获央视新闻联播、焦点访谈等权威媒体专题报道。

代表性期刊论文

[1]Zhang Y, Zhao L*, Du X, Sun Y*. Integrating single-sample networks and genetic algorithm to estimate radiation dose in multiple tissues of mice under space environment. Radiat Res, 2026. In press.

[2]He X, Zhao L*, Li J, Mi D, Han Z, Qi X, et al. Conserved features of radiation response across plants and animals facilitate the identification of a panel of ionizing radiation-responsive genes for human biodosimetry. Int J Radiat Biol, 2026, 102(4): 346-360.

[3]Zhang G, Zhao L*, Li Z, Sun Y. Integrated spaceflight transcriptomic analyses and simulated space experiments reveal key molecular features and functional changes driven by space stressors in space-flown C. elegans. Life Sci Space Res 2025, 44: 10-22.

[4]Zhang G, Zhao L*, Li Z, Dong Y, Ju Z, Sun Y. Low-dose ionizing radiation promotes lifespan extension and stress resistance of C. elegans via DAF-16/SKN-1 mediated adaptive response. Ecotox Environ Safe, 2025, 306: 119333.

[5]Zhang BQ, Zhong RT, ……, Zhao L, et al. The space radiobiological exposure facility on the China Space Station. Astrobiology 2025; 25: 32-41.

[6]Li Z, Zhao L*, Zhang G, Mi D, Sun Y. Optimized combination methods for exploring novel space environment-responsive genes and their roles: insights from space-flown C. elegans and their implications for astronauts. Int J Radiat Biol, 2025; 101: 891-911.

[7]Zhang Y, Zhao L*, Sun Y. Using single-sample networks to identify the contrasting patterns of gene interactions and reveal the radiation dose-dependent effects in multiple tissues of spaceflight mice. npj Microgravity 2024; 10: 45.

[8]Zhang Y, Du XH, Zhao L*, Sun YQ. Construction of dose prediction model and identification of sensitive genes for space radiation based on single-sample networks under spaceflight conditions. Int J Radiat Biol, 2024; 100: 777-790.

[9]He X, Zhao L*, Huang B, Zhang G, Lu Y, Mi D, et al. Integrated analysis of miRNAome and transcriptome reveals that microgravity induces the alterations of critical functional gene modules via the regulation of miRNAs in short-term space-flown C. elegans. Life Sciences in Space Research 2024; 42: 117-132.

[10]Zhao L*, Li Z, Huang B, Mi D, Xu D, Sun Y. Integrating evolutionarily conserved mechanism of response to radiation for exploring novel Caenorhabditis elegans radiation-responsive genes for estimation of radiation dose associated with spaceflight. Chemosphere, 2024, 351: 141148

[11]Zhao L*, Tang, A., Long, F., Mi, D., Sun, Y. Modeling of ionizing radiation-induced chromosome aberration and tumor prevalence based on two classes of DNA double-strand breaks clustering in chromatin domains. Ecotox Environ Safe, 2023, 259:115038.

[12]Zhao L*, Zhang, G., Tang, A., Huang, B., Mi, D. Microgravity alters the expressions of DNA repair genes and their regulatory miRNAs in space-flown Caenorhabditis elegans. Life Sci Space Res, 2023, 37:25-38.

[13]Jiang J, Zhao L, Guo L, Xing Y, Sun Y, Xu D. Integrated analysis of mRNA and miRNA expression profiles in dys-1 mutants of C. elegans after spaceflight and simulated microgravity. Microgravity Sci Technol, 2023, 35(3):31.

[14]Lei X, Zhang W, Zhang Y, Zhao L. Editorial: The regulating mechanisms of development, growth, and metabolism: From ground to space. Front Cell Dev Biol, 2022, 10, 951741.

[15]Zhao L*, Tian J, Borasi G, Mi D, Sun Y. Improved asymptotic expansions in high- and low-dose ranges for generalized multi-hit model of radiation-induced cell survival, Radiat Res, 2021, 196: 306-314.

[16]Zhao L, He X, Shang Y, Bao C, Peng A, Lei X, Han P, Mi D, Sun YQ*. Identification of potential radiation-responsive biomarkers based on human orthologous genes with possible roles in DNA repair pathways by comparison between Arabidopsis thaliana and Homo sapiens, Sci Total Environ, 2020, 702: 135076.

[17]Zhao L*, Chen X, Tian J, Shang Y, Mi D, Sun YQ*. Generalized multi-hit model of radiation-induced cell survival with a closed-form solution: An alternative method for determining isoeffect doses in practical radiotherapy. Radiat Res, 2020, 193: 359-371.

[18]Zhao L*, Bao C, Wang W, Mi D*. New evidence and insight for abnormalities in early embryonic development after short-term spaceflight onboard the Chinese SJ-10 satellite. Life Sci Space Res, 2020, 27: 107-110.

[19]Zhao L*, Bao C, Shang Y, He X, Ma C, Lei X, Mi D*, Sun YQ*. The Determinant of DNA Repair Pathway Choices in Ionising Radiation-Induced DNA Double-Strand Breaks, Biomed Res Int, 2020, 2020: 4834965.

[20]Zhao L*, He X, Chen X, Shang Y, Mi D*, Sun YQ*. Fitting the generalized target model to cell survival data of proton radiation reveals dose-dependent RBE and inspires an alternative method to estimate RBE in high-dose regions. Radiat Res, 2019, 192: 507-516.

[21]Dai ZQ, Lei XH, Yang C, Zhao L, Lu L, Li YH. Systematic biomedical research of the NASA Twins Study facilitates the hazard risk assessment of long-term spaceflight missions. Protein & Cell, 2019, 10: 628-630.

[22]Sun Y, Wang W, Zhang M, Zhao L, Mi D, Zhang B, Zhou D, Zhang SY. Space radiation systems biology research in SJ-10 satellite. Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite. Science Press and Springer Nature Singapore Pte Ltd. 2019, 43-68.

[23]赵磊, 尚钰轩, 袁爽, 何欣叶, 宓东, 孙野青*. 载人深空探索中空间辐射防护技术的研究进展. 科学通报, 2019, 2087-2103. (特约综述)

[24]赵磊, 宓东, 孙野青*. 载人深空探索中空间辐射风险评估所面临的问题和挑战. 科学通报, 2018, 63(16),1523-1537. (特约综述)

[25]Zhou D, Sun Y, Zhang B, Zhang S, Liang J, Zhu G, Jing T, Yuan B, Zhang H, Zhang M, Wang W, Zhao L. Radiation measured for chinese satellite SJ-10 space mission. J Geophys Res-Space Phys, 2018, 123, 1690-1700

[26]Zhao L, Mi D*, Sun YQ*. A novel multitarget model of radiation-induced cell killing based on the Gaussian distribution. J Theor Biol, 2017, 420: 135-143.

[27]Zhao L, Wu D, Mi D*, Sun YQ*. Radiosensitivity and relative biological effectiveness based on a generalized target model. J Radiat Res, 2017, 58(1): 8-16.

[28]Gao Y, Xu d, Zhao L, Sun YQ*, The DNA damage response of C. elegans affected by gravity sensing and radiosensitivity during the Shenzhou-8 spaceflight. Mutat Res / Fund Mol M, 2017, 795: 15-26.

[29]Zhao L, Gao Y, Mi D*, Sun YQ*. Mining potential biomarkers associated with space flight in Caenorhabditis elegans experienced Shenzhou-8 mission with multiple feature selection techniques. Mutat Res / Fund Mol M, 2016, 791: 27-34.

[30]Zhao L, Mi D*, Hu B, Sun YQ*. A generalized target theory and its applications. Sci Rep, 2015, 5: 14568.

[31]Zhao L, Mi D*, Chen Y, Wang L, Sun YQ*. Ecological risk assessment and sources of heavy metals in sediment from Daling River basin. Environ Sci Pollut R, 2015, 22(8): 5975-5984.

[32]Zhao L, Gong N, Mi D, Luan C, Shao K, Jia H, Sun YQ*. Kinetics of stereoselective enrichment of Dechlorane Plus in Ulva Pertusa. Chemosphere, 2014, 111: 580-586.

个人网页

ORCID ID:orcid.org/0000-0001-5912-2676

ResearchGate:https://www.researchgate.net/profile/Lei_Zhao99

联系方式

通信地址：辽宁省大连市大连海事大学西山校区生物楼

电子邮箱：zhaol@dlmu.edu.cn